SMIP-016 in Action: CD37 as a Death Receptor
نویسندگان
چکیده
منابع مشابه
Targeting CD37-positive lymphoid malignancies with a novel engineered small modular immunopharmaceutical.
CD37 is a lineage-specific B-cell antigen that to date has been neglected as an attractive therapeutic target. To exploit this, novel CD37-specific small modular immunopharmaceuticals (CD37-SMIP) that include variable regions linked to modified human IgG(1) hinge, CH(2), and CH(3) domains were designed. The lead CD37-SMIP molecule induces potent apoptosis in the presence of a cross-linker, and ...
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ژورنال
عنوان ژورنال: Cancer Cell
سال: 2012
ISSN: 1535-6108
DOI: 10.1016/j.ccr.2012.04.034